But now the Centers for Disease Control and Prevention (CDC) has issued a health alert for a unusual new illness striking people under the age of 21 dubbed multisystem inflammatory syndrome in children (MIS-C)-and experts believe it has a link to COVID-19.
"The symptoms in children are different from adults with COVID-19 in whom the illness is more of a respiratory condition", said Dr. George Ofori-Amanfo, division chief of Pediatric Critical Care at Mount Sinai Kravis Children's Hospital, New York.
According to an article by doctors at Evelina published in The Lancet, the hospital had seen 20 cases of the disease in children as of last week, the youngest of whom was four years old.
In New York, the US epicenter of the coronavirus pandemic, more than 100 cases of pediatric multi-system inflammatory syndrome, or PMIS, are being investigated as of Wednesday, May 13.
The state had been investigating 17 possible cases of the illness, which has infected children in at least 15 states and shares similarities with Kawasaki disease.
The syndrome was first seen by doctors in the United Kingdom, but reports of cases in the United States have popped up in recent days.
None of the 10 children died, but their symptoms were more severe than those experienced by the children with Kawasaki disease.
Italian doctors have reported evidence linking the novel coronavirus with a Kawasaki-like inflammatory disease. The patients were 5, 7, and 18 years old.
Suspected COVID-19 hospitalizations rose from 59 on May 12 to 78 on May 13, the percentage of people testing positive rose from 11 percent on May 12 to 12 percent on May 13, but the number of ICU patients dropped from 517 to 506, city data show.
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"We have other patients that we're concerned [about], and we're doing thorough evaluations and we're looking for alternative causes for their fevers and high inflammation", said Dr. Ann Murray, a pediatric infectious disease specialist at Mass. "So, given the numbers and given the fact it's not acting exactly like Kawasaki, it looks like it's probably a post-COVID-19 infection inflammatory disease".
Indeed, the surge in PIMS cases appears to lag several weeks behind the peak in Covid-19 infections across the general population, suggesting that antibodies may play a role in triggering the symptoms. If he's under 21, Dr. Daskalakis says to report it to the health department immediately, even if he has received a negative coronavirus test.
Inflammatory syndrome in children recorded in Europe and North America on the background of the coronavirus pandemic, requires urgent attention of the worldwide community.
"These patients all seem to be associated with the COVID-19", he said.
"All children were previously fit and well", said the report in The Lancet.
Symptoms include fever, abdominal pain and Cardiac issues and are a mix of those for Kawasaki disease and toxic shock syndrome.
"I have to say, I don't think it would have any impact, to be honest", she said at a daily briefing on Wednesday.
"The good news is that, like Kawasaki disease, nearly all the kids are treatable", he added.