As Rajasingham and her colleagues report in the New England Journal of Medicine, 107 of the 821 participants developed disease; 49 in the group receiving hydroxychloroquine and 58 in the placebo group.
He later said he took the drugs preventively after two people who worked at the White House were diagnosed with COVID-19.
Earlier on Wednesday, the World Health Organization announced it was resuming the hydroxychloroquine arm of its Solidarity trial into potential treatments for COVID-19 following a pause to check for any potential safety concerns such as heart problems.
Several trials of the drug have been stopped over concerns about its safety for treating COVID-19 patients raised by health regulators and previous less rigorous studies and.
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The study found that hospitalized Covid-19 patients who were treated with the anti-malaria drugs hydroxychloroquine or chloroquine, either alone or in combination with a macrolide, were associated with an increased risk of death and increased risk of developing ventricular arrhythmias.
As many as 3,100,711 people have recovered from Covid-19, which has spread to 213 countries and territories across the world.
"I think both sides - one side who is saying "this is a risky drug" and the other side that says "this works" -neither is correct", said Boulware.
Surgisphere Corporation, an IL based company which owns the dataset behind the study published in The Lancet as well as a study in the New England Journal of Medicine, has been subject to scrutiny in recent days as clinicians and researchers challenge the likelihood of assembling the amount of data supplied by the firm in such a short period of time. Hydroxychloroquine has always been used for malaria, lupus and rheumatoid arthritis, but no large studies have shown it or chloroquine to be safe or effective for much sicker patients with coronavirus, and some studies have suggested the drugs may do harm. In its revised advisory on May 22, ICMR had recommended prophylactic use of hydroxychloroquine in select categories of people, including all asymptomatic healthcare workers involved in containment and treatment of coronavirus and asymptomatic healthcare workers working in non-coronavirus hospitals or non-COVID areas of corona hospitals and blocks. The Lancet journal issued an "expression of concern" over the study on Wednesday. Social distancing also plays a key role in preventing transmission, with a 1-meter buffer between people significantly reducing the risk, the researchers said.
"The Data Safety and Monitoring Committee will continue to closely monitor the safety of all therapeutics being tested in the Solidarity Trial", added Dr Tedros. Researchers said the subjects were by and large healthy and young, with an average age of 40.